Unified Design of chromatographic separation processes in non-ideal conditions – influence of NTP on the shape and position of the feasible operating parameter space
Kavun, Vitalii (2016)
Diplomityö
2016
Julkaisun pysyvä osoite on
http://urn.fi/URN:NBN:fi-fe2016101725325
http://urn.fi/URN:NBN:fi-fe2016101725325
Tiivistelmä
The investigation of the influence of the number of theoretical plates (NTP) on the region of feasible operating parameters was carried out by conducting a set of simulations with using special software MATLAB.
One part of modelling was devoted to batch chromatography separation of glucose and fructose under non-ideal conditions. To obtain the feasible operating region for this process the Unified Design method was applied. The key parameters of this method were calculated and boundaries of complete separation regions were found. The simulations were performed for different purity requirements (80%, 90% and 99.9%) and with different column efficiency. It was established that at certain (or minimum required value) NTP the operating boundaries at non-ideal conditions is close to be described by the boundaries of the region under ideal conditions. In order to verify it the additional simulations were done with different isotherm parameters for glucose and fructose. The one Henry constants were taken from the literature (for Dowex Monosphere 99/Ca gel type resin), another - were derived for the experimental column in the LUT laboratory, which was packed with Finex CS11GC gel type resin in Ca2+ form. The minimum number of theoretical plates was obtained for each purity constraints and type of the applied adsorbents. It was determined that for low requirements of the product purity the lower NTP is needed to use the operating parameters as for the separation region under ideal conditions.
Further study was devoted to SSR chromatography. The operating parameters obtained from batch simulations were used to design SSR, where showed its applicability. In addition, the productivity and eluent consumption of SSR were compared with batch chromatography.
One part of modelling was devoted to batch chromatography separation of glucose and fructose under non-ideal conditions. To obtain the feasible operating region for this process the Unified Design method was applied. The key parameters of this method were calculated and boundaries of complete separation regions were found. The simulations were performed for different purity requirements (80%, 90% and 99.9%) and with different column efficiency. It was established that at certain (or minimum required value) NTP the operating boundaries at non-ideal conditions is close to be described by the boundaries of the region under ideal conditions. In order to verify it the additional simulations were done with different isotherm parameters for glucose and fructose. The one Henry constants were taken from the literature (for Dowex Monosphere 99/Ca gel type resin), another - were derived for the experimental column in the LUT laboratory, which was packed with Finex CS11GC gel type resin in Ca2+ form. The minimum number of theoretical plates was obtained for each purity constraints and type of the applied adsorbents. It was determined that for low requirements of the product purity the lower NTP is needed to use the operating parameters as for the separation region under ideal conditions.
Further study was devoted to SSR chromatography. The operating parameters obtained from batch simulations were used to design SSR, where showed its applicability. In addition, the productivity and eluent consumption of SSR were compared with batch chromatography.