Study of optical properties of pharmaceutical tablets by THz-TDS spectroscopy method
Troshkin, Dmitrii (2018)
Diplomityö
2018
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi-fe2018050419375
https://urn.fi/URN:NBN:fi-fe2018050419375
Tiivistelmä
In frames of this work optical properties of FCC and lactose tablet samples were examined using THz-TDS method. A THz-TDS setup was designed and assembled for these purposes.
The FFT for the TD data of the samples was used in order to obtain spectrum of the samples in THz range. The further mathematical analysis made it possible to obtain effective refractive index and absorption coefficient of the samples. Such crucial physical parameters of the sample as porosity and mass were calculated using effective media approximations.
THz-TDS method combines the accuracy and simplicity of use, allows to investigate a wide range of materials, composition and physical properties and thus can be used as non-destructive and non-invasive method of quality control of each pharmaceutical tablet in the production line during manufacturing.
The FFT for the TD data of the samples was used in order to obtain spectrum of the samples in THz range. The further mathematical analysis made it possible to obtain effective refractive index and absorption coefficient of the samples. Such crucial physical parameters of the sample as porosity and mass were calculated using effective media approximations.
THz-TDS method combines the accuracy and simplicity of use, allows to investigate a wide range of materials, composition and physical properties and thus can be used as non-destructive and non-invasive method of quality control of each pharmaceutical tablet in the production line during manufacturing.